Publications

Julian O Streit, Ivana V Bukvin, Sammy HS Chan, Shahzad Bashir, Lauren F Woodburn, Tomasz Włodarski, Angelo M Figueiredo, Gabija Jurkeviciute, Haneesh K Sidhu, Charity R Hornby, Christopher A Waudby, Lisa D Cabrita, Anaïs ME Cassaignau, John Christodoulou (2024). The ribosome lowers the entropic penalty of protein folding.. Nature.

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Tomasz Włodarski, Julian O Streit, Alkistis Mitropoulou, Lisa D Cabrita, John Christodoulou (2024). Bayesian reweighting of biomolecular structural ensembles using heterogeneous cryo-EM maps with the cryoENsemble method.. Scientific Reports.

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Sammy H S Chan, Tomasz Włodarski, Julian O Streit, Anaïs M E Cassaignau, Lauren F Woodburn, Minkoo Ahn, Georg Johannes Freiherr von Sass, Christopher A Waudby, Nediljko Budisa, Lisa D Cabrita, John Christodoulou (2022). The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein.. Nature Chemistry.

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Minkoo Ahn, Tomasz Włodarski, Alkistis Mitropoulou, Sammy H S Chan, Haneesh Sidhu, Elena Plessa, Thomas A Becker, Nediljko Budisa, Christopher A Waudby, Roland Beckmann, Anaïs M E Cassaignau, Lisa D Cabrita, John Christodoulou (2022). Modulating co-translational protein folding by rational design and ribosome engineering.. Nature Communications.

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Annika Deckert, Anaïs M E Cassaignau, Xiaolin Wang, Tomasz Włodarski, Sammy H S Chan, Christopher A Waudby, John P Kirkpatrick, Michele Vendruscolo, Lisa D Cabrita, John Christodoulou (2021). Common sequence motifs of nascent chains engage the ribosome surface and trigger factor.. Proceedings of the National Academy of Sciences of the United States of America.

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Charles Burridge, Christopher A Waudby, Tomasz Włodarski, Anaïs M E Cassaignau, Lisa D Cabrita, John Christodoulou (2021). Nascent chain dynamics and ribosome interactions within folded ribosome-nascent chain complexes observed by NMR spectroscopy.. Chemical science.

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Anaïs M E Cassaignau, Tomasz Włodarski, Sammy H S Chan, Lauren F Woodburn, Ivana V Bukvin, Julian O Streit, Lisa D Cabrita, Christopher A Waudby, John Christodoulou (2021). Interactions between nascent proteins and the ribosome surface inhibit co-translational folding.. Nature Chemistry.

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Abid Javed, Lisa D. Cabrita, Anaïs M.E. Cassaignau, Tomasz Włodarski, John Christodoulou, Elena V. Orlova (2019). Visualising nascent chain dynamics at the ribosome exit tunnel by cryo-electron microscopy. BioRxiv.

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Christopher A Waudby, Tomasz Włodarski, Maria-Evangelia Karyadi, Anaïs M E Cassaignau, Sammy H S Chan, Anne S Wentink, Julian M Schmidt-Engler, Carlo Camilloni, Michele Vendruscolo, Lisa D Cabrita, John Christodoulou (2018). Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.. Proceedings of the National Academy of Sciences of the United States of America.

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Rodrigo A F Redondo, Harold P de Vladar, Tomasz Włodarski, Jonathan P Bollback (2017). Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family.. Journal of the Royal Society, Interface.

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Annika Deckert, Christopher A Waudby, Tomasz Włodarski, Anne S Wentink, Xiaolin Wang, John P Kirkpatrick, Jack F S Paton, Carlo Camilloni, Predrag Kukic, Christopher M Dobson, Michele Vendruscolo, Lisa D Cabrita, John Christodoulou (2016). Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor.. Proceedings of the National Academy of Sciences of the United States of America.

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Lisa D Cabrita, Anaïs M E Cassaignau, Helene M M Launay, Christopher A Waudby, Tomasz Włodarski, Carlo Camilloni, Maria-Evangelia Karyadi, Amy L Robertson, Xiaolin Wang, Anne S Wentink, Luke Goodsell, Cheryl A Woolhead, Michele Vendruscolo, Christopher M Dobson, John Christodoulou (2016). A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.. Nature Structural & Molecular Biology.

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Tomasz Włodarski, Jan Kutner, Joanna Towpik, Lukasz Knizewski, Leszek Rychlewski, Andrzej Kudlicki, Maga Rowicka, Andrzej Dziembowski, Krzysztof Ginalski (2011). Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.. Plos One.

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Tomasz Włodarski, Bojan Zagrovic (2009). Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin.. Proceedings of the National Academy of Sciences of the United States of America.

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